Bad combination: how to accept correctly

Combination of dietary supplements: how to accept correctly – complete leadership

I. Fundamentals of a combination of dietary supplements: knowledge – the key to safety and efficiency

1. What is dietary supplements and why is the question of a combination?

   • Determination of dietary supplements (biologically active additives): composition, form of release, regulatory aspects (or their absence, depending on the country). Detailed analysis: vitamins, minerals, amino acids, plant extracts, probiotics, prebiotics, enzymes, fatty acids and others.
   • The reasons for the popularity of dietary supplements: the desire to improve health, compensation for nutrient deficiency, maintain certain body functions, prevention and marketing, and accessibility.
   • Why the question arises of a combination: polypragmasia (taking several drugs at the same time), the desire for a synergistic effect, ignorance of potential interactions, a desire to solve several problems in one fell swoop.
   • The risks of improper combination: reducing the effectiveness of one or more dietary supplements, increased side effects, the development of new side effects, toxicity, interaction with drugs.
   • The importance of consultation with a specialist: a doctor, a nutritionist, nutritionist, a pharmacist – their role in the selection and a combination of dietary supplements. Assessment of individual needs, health status, drug therapy, potential risks.

2. Key principles of safe and effective combination of dietary supplements:

   • Principle 1: Individual approach. Accounting for age, gender, health status (the presence of chronic diseases, allergies, individual intolerance), lifestyle, food habits, drugs taken.
   • Principle 2: Assessment of needs. Analysis of the diet, the identification of nutrient deficiency, determination of the goals of intake of dietary supplements (prevention, support, treatment).
   • Principle 3: Studying the composition and dosage. A careful reading of labels, the study of active ingredients, excipients, dosages, contraindications, side effects.
   • Principle 4: Understanding the mechanisms of action. Knowing how every dietary supplement affects the body, what processes it regulates, how it interacts with other substances.
   • Principle 5: Accounting for possible interactions. The study of well -known interactions between dietary supplements, between dietary supplements and medicines, between dietary supplements and food. Using databases and reference books to verify interactions.
   • Principle 6: observation of the reaction of the body. Attentive monitoring of changes in the state of health, the appearance of side effects, changes in analyzes. Maintaining a diary of receiving dietary supplements and tracking well -being.
   • Principle 7: gradual introduction. Start with small doses, gradually increasing them to the recommended. Enter new dietary supplements by one in order to track the body’s reaction to each of them.
   • Principle 8: Cycling of admission. Avoid prolonged continuous admission of dietary supplements. Take breaks between reception courses so that the body does not get used to additives and retains sensitivity to them.
   • Principle 9: Quality and safety. The choice of dietary supplements from trusted manufacturers with a good reputation and comply with quality standards. Checking the availability of quality and safety certificates.
   • Principle 10: Consultation with a specialist. Regular consultations with a doctor, nutritionist or nutritionist to assess the effectiveness and safety of admission of dietary supplements, adjust the dosages and reception schemes.

3. Classification of dietary supplements:

   • Synergyism: Strengthening the action of one dietary supplement to another. Examples: vitamin C and iron, vitamin D and calcium, curcumin and pipin.
   • Antagonism: Weakening of the action of one dietary supplement to another. Examples: iron and calcium, zinc and copper, vitamin E and vitamin K.
   • Additative effect: Summing up the effects of two or more dietary supplements. It can be either useful (for example, with a joint administration of antioxidants) and harmful (for example, with a joint administration of dietary supplements with a sedative effect).
   • Influence on absorption: one dietary supplement can improve or worsen the absorption of another. Examples: Vitamin C improves iron absorption, fiber worsens the absorption of many dietary supplements.
   • Influence on metabolism: one dietary supplement can affect the metabolism of another, changing its concentration in the blood. Examples: Grapefruit juice inhibits enzymes that break down many drugs and dietary supplements.
   • Competition for receptors: two or more dietary supplements can compete for connecting with the same receptors in the body. Examples: L-tyrosin and L-tripthophanes compete for transport through a hematoencephalic barrier.
   • Influence on excretion: one dietary supplement can affect the elimination of another from the body, changing its half -life. Examples: diuretics increase the elimination of potassium from the body.

II. Practical examples of a combination of dietary supplements: Guide to safe and effective combinations

1. Vitamins and minerals: optimal combinations and potential risks.

   • Vitamin C and iron: synergism, improvement of iron absorption. Recommendations for dosage and reception time. Restrictions for people with hemochromatosis.
   • Vitamin D and calcium: synergism, improvement of calcium absorption, support of bone health. The importance of simultaneous intake of vitamin K2. Optimal dosages of vitamin D, depending on age and level in the blood.
   • B vitamins B: synergism, complex effect on the nervous system, energy metabolism, hematopoiesis. The importance of the balance between different vitamins of group B. Recommendations for choosing a complex of vitamins of group B.
   • Zinc and copper: antagonism, zinc can reduce the absorption of copper. Recommendations for separate intake of zinc and copper, especially with high doses of zinc. The ratio of zinc and copper in addition.
   • Calcium and magnesium: synergism, support for the health of bones, muscles, nervous system. The importance of the ratio of calcium and magnesium in the diet and additives. Forms of calcium and magnesium with better bioavailability.
   • Vitamin E and vitamin K: antagonism, high doses of vitamin E can affect blood coagulation and enhance the effect of anticoagulants (vitamin K is involved in blood coagulation). Caution when taking high doses of vitamin E simultaneously with anticoagulants.
   • Potassium and magnesium: synergism, important for electrolyte balance and heart health. Magnesium deficiency can aggravate potassium deficiency.
   • Iron and calcium: antagonism, calcium can reduce iron absorption. Recommendations for separate administration of iron and calcium preparations.
   • Vitamin A and Vitamin E: Synergism, vitamin E can protect vitamin A from oxidation.

2. Probiotics and prebiotics: support for the intestinal microbioma.

   • Probiotics: living microorganisms that have a beneficial effect on the intestinal microflora. The choice of probiotic strains depending on the purpose of the reception (diarrhea, constipation, immunity).
   • Prebiotics: dietary fiber that serve as a nutrient medium for probiotics. Examples of prebiotics: inulin, fructoligosaccharides (phos), galactooligosaccharides (state).
   • Synergyism of probiotics and prebiotics: improving the survival and activity of probiotics, supporting a healthy microbioma. Examples of synbiotics (a combination of probiotics and prebiotics).
   • The interaction of probiotics with antibiotics: probiotics can reduce the side effects of antibiotics (diarrhea, dysbiosis). Recommendations on the time of taking probiotics during and after the course of antibiotics.
   • Possible side effects of probiotics: bloating, gases. Start with small doses, gradually increasing them.

3. Plant extracts: enhancement and weakening of effects.

   • Kurkumin and Piperin: synergism, piperin (contained in black pepper) increases the bioavailability of curcumin. Recommendations for the joint administration of Kurkumin and Piperin.
   • St. John’s wort and antidepressants: St. John’s wort can interact with antidepressants, changing their concentration in the blood and increasing side effects. The joint use of St. John’s wort and antidepressants without consulting a doctor is contraindicated.
   • Green tea and iron: green tea contains tannins that can reduce iron absorption. Recommendations for separate intake of green tea and iron preparations.
   • Echinacea and immunomodulators: Echinacea has an immunomodulating effect. The joint intake of echinacea with other immunomodulators without consulting a doctor is not recommended.
   • Valerian and Melatonin: Synergism, both have a calming and sleeping pill. They can be used together to improve sleep, but you should start with low doses.

4. Amino acids: competition for assimilation and interaction with neurotransmitters.

   • L-tyrosine and L-tripthophanes: competition for transport through a hematoencephalic barrier. Simultaneous intake of L-grosin and L-tripthophanes is not recommended.
   • BCAA (amino acids with an extensive chain) and L-lutamine: BCAA can improve the absorption of L-lutamine. The combination of BCAA and L-lutamine can be useful for recovery after training.
   • L-Arginine and L-Citrullin: Synergism, L-Citrullin turns into L-arginine in the body, increasing the level of L-arginine in the blood more efficiently than L-Arginine itself. The combination of L-arginine and L-digitaline can improve blood circulation and physical endurance.
   • Glycine and Taurin: synergism, both have a calming effect and can improve sleep.
   • 5-HTP (5-hydroxyryptophan) and L-tyrosine: caution should be observed, as both affect the neurotransmitter level and can cause an imbalance if you take them in high doses or at the same time without consulting a specialist.

5. Fatty acids: improvement of assimilation and interaction with other substances.

   • Omega-3 and vitamin E: synergism, vitamin E protects omega-3 fatty acids from oxidation. Recommendations for the joint reception of Omega-3 and Vitamin E.
   • Omega-3 and aspirin: omega-3 fatty acids have an anticoagulant effect, so the joint intake of omega-3 and aspirin can increase the risk of bleeding. Caution with the joint administration of omega-3 and anticoagulants.
   • Omega-3 and Coenzym Q10: they can enhance the action of each other, supporting the cardiovascular system.

6. Enzymes: Improving digestion and assimilation of nutrients.

   • Proteolithic enzymes (for example, Bromelein, Papain) and anti -inflammatory drugs: Proteolithic enzymes can enhance the effect of anti -inflammatory drugs.
   • Lipaza and Omega-3: Lipase can help in splitting fat, improving the absorption of omega-3 fatty acids. Especially relevant for people with digestive problems.

III. Interaction of dietary supplements with drugs: extremely important information

1. General principles of interaction between dietary supplements and drugs:

   • Pharmacokinetic interaction: BAD affects the absorption, distribution, metabolism or excretion of the drug.
   • Pharmacodynamic interaction: Bad enhances or weakens the effect of the drug at the level of receptors or other mechanisms of action.
   • Increasing the risk of side effects: the joint intake of dietary supplement and the drug can increase the risk of side effects.
   • Reducing the effectiveness of the drug: Bad can reduce the effectiveness of the drug, requiring the dose of drug.
   • The importance of informing the doctor: it is necessary to inform the doctor about all the dietary supplements in order to avoid undesirable interactions with drugs.

2. Examples of specific interactions of dietary supplements and drugs:

   • St. John’s wort and antidepressants (SSRI): St. John’s wort can increase the level of serotonin, which can lead to serotonin syndrome with joint intake with SSRI.
   • St. John’s wort and warfarin: St. John’s wort can reduce the effectiveness of warfarin, increasing the risk of thrombosis.
   • Vitamin K and warfarin: Vitamin K can reduce the effectiveness of warfarin, as vitamin K is involved in blood coagulation.
   • Grapefruit juice and statins: grapefruit juice can increase blood statins, increasing the risk of side effects.
   • Coenzym Q10 and statins: statins can reduce the level of Q10 coenzyme in the body, so it can be useful to take Q10 coenzyme simultaneously with statins.
   • Garlic and anticoagulants: garlic has an anticoagulant effect, so the joint intake of garlic and anticoagulants can increase the risk of bleeding.
   • Ginseng and warfarin: ginseng can affect blood coagulation and interact with warfarin.
   • Kava-kawa and antidepressants/anxiolytics: Kava-kawa can enhance the effect of these drugs, leading to excessive sedation.
   • Magnesium and antibiotics (tetracyclines, chinolons): Magnesium can reduce the absorption of these antibiotics.
   • Iron and levotiroxin: iron can reduce the absorption of levotyroxine (thyroid hormone).

3. Recommendations on the prevention of interactions of dietary supplements and drugs:

   • Tell the doctor about all the dietary supplements.
   • Check the potential interactions of dietary supplements and drugs using online bases or consultations with a pharmacist.
   • Take dietary supplements and medicines at different times of the day to minimize the risk of interaction.
   • Start with small doses of dietary supplements to evaluate the reaction of the body.
   • Carefully follow your well -being and inform the doctor about any unusual symptoms.
   • Do not take dietary supplements if you have chronic diseases or you take medications without consulting a doctor.

IV. Individual factors and a combination of dietary supplements: we take into account the state of health and age

1. Health status:

   • Cardiovascular diseases: omega-3, coenzyme Q10, magnesium, potassium. Caution with dietary supplements affecting blood coagulation.
   • Diabetes: chrome, cinnamon, alpha-lipoic acid. Caution with dietary supplements affecting blood sugar.
   • Thyroid diseases: selenium, iodine (only with deficiency). Caution with dietary supplements affecting the function of the thyroid gland.
   • Liver and kidney diseases: restriction of dietary supplements requiring active metabolism in the liver or kidney excretion. Consultation with a doctor is required.
   • Autoimmune diseases: vitamin D, probiotics. Caution with immunomodulators.
   • Allergies and individual intolerance: careful study of the composition of dietary supplements, avoid allergens.

2. Age:

   • Children: a limited list of dietary supplements, only as prescribed by a doctor. Vitamin D, vitamin K2 (for newborns), omega-3.
   • Teenagers: vitamin D, calcium, iron (especially for girls).
   • Adults: vitamins of group B, vitamin D, magnesium, omega-3, probiotics (depending on needs).
   • Elderly people: vitamin D, calcium, vitamin B12, omega-3, coenzyme Q10. Accounting for age -related changes in metabolism and deduction of dietary supplements.
   • Pregnancy and breastfeeding: folic acid, iron, calcium, vitamin D, omega-3. A limited list of dietary supplements, only as prescribed by a doctor.

3. Genetic factors:

   • Genes polymorphisms affecting the metabolism of vitamins and minerals. For example, MPFR polymorphisms affecting folic acid metabolism.
   • Genetic tests for determining individual needs for nutrients.
   • Individual selection of dietary supplements based on genetic data.

V. How to evaluate the effectiveness of a combination of dietary supplements: monitoring and correction

1. Maintaining a dietary supplement diary:

   • Record of the names of dietary supplements, dosages, reception time.
   • Recording changes in well -being, the appearance of side effects.
   • Recording changes in the symptoms for which dietary supplements are taken.
   • Analysis of the dietary supplement for evaluating effectiveness and safety.

2. Monitoring of health indicators:

   • Regular blood tests to assess the level of vitamins, minerals, hormones.
   • Measurement of blood pressure, pulse, blood sugar levels.
   • Assessment of liver and kidney function.
   • Consultations with a doctor to assess the dynamics of health indicators.

3. Correction of a dietary supplement reception scheme:

   • Changing dosages of dietary supplements depending on efficiency and tolerance.
   • Replacing dietary supplements with analogues with better bioavailability or less side effects.
   • The exclusion of dietary supplements that do not have a positive effect or cause side effects.
   • Adding new dietary supplements to achieve the desired result.

4. Efficiency assessment criteria:

   • Improving well -being and quality of life.
   • Reducing the symptoms of the disease.
   • Normalization of health indicators.
   • Lack of side effects.

VI. Myths and misconceptions about the combination of dietary supplements: we debunk inaccurate information

1. Myth 1: The more dietary supplements, the better.

   • Reality: polypragmasia can be dangerous and lead to undesirable interactions, side effects and decreased efficiency.
   • The importance of an individual approach and evaluate the needs of the body.

2. Myth 2: Bades are natural products, so they are safe.

   • Reality: some dietary supplements may contain toxic substances or interact with drugs. It is necessary to choose dietary supplements from trusted manufacturers and consult a doctor.

3. Myth 3: Bad can be taken without consulting a doctor.

   • Reality: you need to consult a doctor, especially if you have chronic diseases or you take medicines.
   • The doctor will help to choose the optimal dietary supplement scheme, taking into account your individual needs and risks.

4. Myth 4: Dietary supplements act instantly.

   • Reality: It takes time to achieve the effect of receiving dietary supplements.
   • It is necessary to take dietary supplements regularly and for a sufficiently long period of time.

5. Myth 5: All dietary supplements are equally effective.

   • Reality: the effectiveness of dietary supplements depends on the quality, dosage, form of release and individual characteristics of the body.
   • It is necessary to choose dietary supplements from trusted manufacturers and with high bioavailability.

6. Myth 6: A combination of several dietary supplements always enhances their action.

   • Reality: a combination can lead to antagonism, a decrease in efficiency or enhance side effects.
   • It is important to understand the mechanisms of the action of each dietary supplement and take into account possible interactions.

VII. Future combination of dietary supplements: prospects and new directions

1. Personalized nutrition:

   • Individual selection of dietary supplements based on genetic data, analysis of microbioma, metabolomics.
   • Optimization of dosages and dietary supplements, taking into account the individual characteristics of the body.

2. Development of new dietary supplements with improved bioavailability and safety:

   • The use of nanotechnologies to improve dietary supplements.
   • Development of dietary supplements with prolonged action.
   • Creation of dietary supplements with a minimum number of side effects.

3. Creation of interactive databases on the interaction of dietary supplements:

   • Access to information on the interaction of dietary supplements for doctors and patients.
   • Development of mobile applications for checking dietary supplements.

4. Expanding studies on the interaction of dietary supplements and drugs:

   • Conducting clinical studies to assess the effectiveness and safety of a combination of dietary supplements and drugs.
   • The study of the effect of dietary supplements on the metabolism of drugs.

5. Increasing the awareness of the population about the proper application of dietary supplements:

   • Conducting educational programs for patients and doctors.
   • Distribution of information about the risks and advantages of admission of dietary supplements.

This article provides a comprehensive overview of combining dietary supplements, covering everything from the basics to potential interactions and future trends. It emphasizes the importance of individualization, expert consultation, and evidence-based decision-making.